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予防医療データベースにおいて情報共有を行っていくトピック一覧（予定）

一般社団法人 日本プライマリ・ケア連合学会予防医療・健康増進委員会 予防医療チーム

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The most crucial toughness of this research was that the urine samples were being gathered in 17 communities with various characteristics throughout four Asian countries; this enabled an unbiased investigation of associations amongst urinary large metal concentrations and blood pressure for the regional degree. Analyze constraints provided measuring the total As concentrations of your urine samples with no speciation Evaluation to differentiate among publicity to poisonous inorganic As and non-harmful organic and natural As compounds. In addition, we assessed significant steel publicity stages utilizing solitary location urine samples. To assess the systemic overall body burdens of Pb and Se, it may are already advantageous to examine their concentrations in full blood, erythrocytes, or serum/plasma samples [seventy one, 72].

東京慈恵会医科大学心臓外科 主任教授。医師。医学博士。日本およびドイツで数多くの心臓外科手術を経験している。北海道大学医学部卒業。 社外取締役　縄田 寛

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Despite the fact that former reports found that high urinary As concentrations tended for being connected with blood pressure level, the direction of your association stays unclear, particularly in populations subjected to rather reduced levels of As. Inorganic As metabolism differs involving people today due to genetic polymorphisms while in the As (+three oxidation point out) methyltransferase gene [sixty seven]. This implies that susceptibility to As toxicity may perhaps vary amongst people today, which might have led to your conflicting brings about the literature.

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Desk 6 offers the final results of many linear regression analyses analyzing the associations among urinary hefty metallic concentrations and hypertension in all individuals (covariates: country, age, sexual intercourse, and BMI). Statistically major associations were not found concerning urinary As concentrations and blood pressure level. Urinary focus of Pb was positively linked to each SBP and DBP, though urinary Se focus of Se was negatively associated with them. All values of VIF ended up under one.

We uncovered that urinary Pb concentration was positively linked to SBP and DBP in people of 4 Asian countries. Notably, this Affiliation was existing during the context of minimal urinary Pb concentrations, supporting the toxicity of Pb with regard to hypertension amongst populations in non-contaminated regions.